General Biochemistry
Fall -
2011
Lectures -
MWF 11:00-11:50 AM VH 131
PreTest
and Study Guide
Lecture Links (below) are to Handouts. Example OLD
EXAM.
Principles of
STUDY
| Instructor | Phone | Office hours | |
| John Makemson |
makemson@fiu.edu |
305-348-3097 |
OE 246/7: MTWF After 3P< |
Tentative Syllabus
Lecture PowerPoint figures (or Exam Answers and
Scores) are
available by clicking on
the lecture topic for that day. They are all in pdf format.
| Aug |
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| 22 M | Biological
Logic and Cell Structure |
Ch 1 | Finish End of Chapter Practice Problems.
These exercise your control of units and simple math.
Remember: a number is meaningless without units. Always remember
that answers
on exams without units get zero points. Numbers are meaningless without
units. DO THESE PROBLEMS NOW Solutions
Chapter 1 Problems |
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| 24 W | Water,
pKa, Buffers |
Ch 2 | End of Chapter Problems here are like that on
the Exam...know them NOW. Solutions
Chapter 2 Problems |
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| 26 F |
Water, pKa, Buffers Exam 1 |
Ch 2 | Exam 1 during the last 25 minutes of the lecture; 50 points |
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| 29 M |
Amino
Acids |
Ch 3 |
Problem set exercises not only amino
acid chemistry, but sequencing proteins. Solutions
to Chapter 3 Problems |
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| 31 W |
Amino Acids, Protein Purification | Ch 3 |
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| Sept |
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| 2 F |
Finish Ch3 |
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| 5 M |
LABOR DAY HOLIDAY |
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| 7 W | Proteins 3-D Structure | Ch4 |
Problem set here is excellent. You need to know these well before lectures on Protein Function and Enzymes. | ||
| 9 F |
EXAM 2 |
Exam 2, 100 points, bring non-graphing
calculator. Integrates material from Chapter 2 |
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| 12 M | Protein Function | Ch 5 |
Hemoglobin and
Myoglobin are the models for
changes of protein strcuture and biological
activity/relevance. Solutions |
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| 14 W |
Enzymes | Ch6 |
Start the problems now, you need to know how to make Michaelis-Menton and Lineweaver-Burk plots: the exam will have you do these! Knowing how to graph is simple and necessary! Problems Solutions |
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| 16 F |
Enzymes, con't |
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| 19 M |
Enzymes, con't |
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| 21 W |
Enzymes |
Ch7 |
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| 23 F |
EXAM 3 | 100 points. You need to bring: No 2.
Pencils, Simple
Scientific Calculator+ Straight Edge (ruler), This exam
integrates material fromChapters 3 and 4. Exam Key and
Distribution After the Exam Please read course policies about CALCULAOTRS |
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| 26 M |
Carbohydrates | Ch7 |
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| 28 W |
Carbohydrates |
Ch 7 |
Problems with carbohydrate chemistry and glycosidic links: Get them done NOW!!...and known well before the next exam. | ||
| 30 F |
Nucleic Acids | Ch 8 |
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| Oct |
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| 3 M |
Nucleic Adids |
Ch 8 |
Problem set is great with nucleotide and DNA/RNA. | ||
| 5 W |
Nucleic Acids, con't | Ch 8 |
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| 7 F |
EXAM 4 |
100 points, integrates material from Chapter 3
and 6. Be sure to bring your calculator. |
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| 10 M |
Lipids | Ch10 |
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| 12 W |
Membranes and Transport | Ch11 |
Membranes, life would not exist without them...know how to do the problems Now....quick, the exam is coming up. . | ||
| 14 F |
Membranes and Transpor | ||||
| 17 M |
Biosignalling | Ch12 |
Biosignalling is a membrane based system and phospho-relays. We will not cover everything in the chapter, just the essentials that relate to the metabolic pathways coming up later. Know these well, it will help later. Solutions | ||
| 19 W |
Biosignalling | |
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| 21 F |
EXAM 5 | Integrates material from Ch 3, 5, 6, 7, 8. Be sure to bring your calculator. | |||
| 24 M |
Bioenergetics | Ch13 |
Bioenergetics is simple and striaghtforward, you did all this in General Chem, we just have to make some modifications for Biochem. All the pathways we will cover next relies upon knowing how enzymes work (Chpt 6) and their bioenergetics. Problems | ||
| 26 W |
Bioenergetics, Pathways | Melamine |
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| 28 F |
Glycolysis, Gluconeogenesis and Pentose Phosphate Pathway | Ch14 |
es, you have to know perfectly the chemistry of these pathways...practice as often as you can....these are Central Metabolism and all pathways come back to them...they are used throughout the rest of the course. Solutions | ||
| 31 M |
Glyconeogenesis, PPP | Ch14 |
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| Nov |
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| 2 W |
Citric Acid Cycle | Ch16 |
This is the other Central Metabolism pathway...we will use it extensively in the following chapters. You need to know it perfectly NOW. Problem solutions | ||
| 4 F |
EXAM 6 |
100 points. Be sure to bring your
calculator. |
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| 7 M |
Glucose
and Glycogen Regulation |
Ch15 |
All major concepts of pathway regulation are
here. We will be doing them in modified forms for all other
pathways. It is essentail that you can solve the problems
now...it makes the rest so much easier! Solutions |
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| 9 W |
Chapter 15 con't |
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| 11 F |
VETERAN'S DAY Holiday |
Ch17 |
Study up for Chapter 17th! |
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| 14 M |
Fatty acid oxidation | Ch17 |
Now Here we go...do the problems and see how Beta-oxidation has parallels to the Citric Acid Cycle besides energizing it! Problem set is very helpful. What you need to concentrate on is how nitrogen is dealt with, knowing the Urea cycle perfectly, and generalities of amino acid degradation pathways. Chapter 17 Solutions Chapter 18 Solutions | ||
| 16 W |
Amino acid oxidation | Ch18 |
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| 18 F |
Oxidative Phosphorylation | Ch19 |
All that NADH and FADH2 ends up here. Redox chemistry will be practiced (review Chpt 13) and the various poisons of respiration. Solutions-19 | ||
| 21 M |
EXAM 7 | 100 points. Be sure to
bring your calculator |
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| 23 W |
Photophosphorylation | Ch19 |
Electron transport energized by light. The problem set is great, as well as knowing photosynthetic electron flow and diversity. | ||
| 24-27 |
THANKSGIVING HOLIDY |
Gobble, gobble or Oink, oink. |
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| 28 M |
Carbohydrate Biosynthesis | Ch20 |
We did glycogen synthesis earlier (Chpt 15), now we get to the other major polysaccharides. This is easy if you already know carbohydrate structure (Chpt 7) and sugar metabolism (Chpt 14 and 15). Solutions | ||
| 30 |
Problem Solving |
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| Dec |
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| 7 |
Final EXAM Note Time: 9:45AM to 11:45 AM, OE 134 | Comprehensive. 200 points. After: the graded Exam can be picked up outside OE246. There will be a key and grade distribution on the bulletin board |