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Equivalent ways of representing anc2

anc2 <- lm(TIME2 ~ TIME1 * GROUP)

includes the main effects of TIME1 and GROUP, and their interaction. This could have been written out as:

anc2 <- lm(TIME2 ~ TIME1 + GROUP + TIME1:GROUP)

where TIME1:GROUP means the interaction. There is an update function in R that can also be used, so this is also equivalent.

anc2 <- update(anc1, .~. + TIME1:GROUP)