Department of Chemistry & Biochemistry

Florida International University


Fenfei Leng, PhD

Associate Professor of Biochemistry

Tel: 305-348-3277 Fax: 305-348-3772


    Nanjing University, Nanjing, China, 1986, BS,  Biochemistry

The University of Mississippi Medical Center, 1997, PhD, Biochemistry

Postdoctoral research fellow, Johns Hopkins University, 1997-2001


Research Interests

Transcription-Coupled DNA Supercoiling

Protein-DNA Interactions


Selected Recent Publications

1. Leng, F., Chen, B., and Dunlap, D. (2011) Dividing a supercoiled DNA molecule into two independent topological domains. The Proceedings of the National Academy of Sciences USA, 108: 19973-19978. PDF and PNAS.

2. Chen, B., Xiao, Y., Liu, C., Li, C., and Leng, F. (2010) DNA Linking Number Change Induced by Sequence-Specific DNA-Binding Proteins. Nucleic Acids Research, 38, 3643-3654.

3. Chen, B., Young, J., and Leng, F. (2010) DNA Bending by the Mammalian High Mobility Group Protein AT Hook 2. Biochemistry, 49, 1590-1595.

4. Joynt, S., Morillo, V., and Leng, F. (2009) Binding the Mammalian High Mobility Group Protein AT-hook 2 to AT-Rich Deoxyoligonucleotides: Enthalpy-Entropy Compensation. Biophysical Journal, 96(10):4144-52.

5. Samul, R. and Leng, F. (2007) Transcription-coupled Hypernegative Supercoiling of Plasmid DNA by T7 RNA polymerase in Escherichia coli Topoisomerase I Deficient Strains. Journal of Molecular Biology, 374: 925-35.

6. Cui, T. and Leng, F. (2007) Specific Recognition of AT-Rich DNA Sequences by the Mammalian High Mobility Group Protein AT-hook 2: A SELEX Study. Biochemistry, 46: 13059-66.


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Postdoctoral position available


Dept of Chemistry & Biochemistry


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