Drug and toxicological Analysis
Fluorescent derivatization for trace and microfluidic analysis
Using in-line preconcentration techniques such as solid phase, affinity and monolithic extraction, we isolate trace levels of drugs of abuse from biological samples. Recent work using monolithic CEC with benzodiazepines and tricyclic antidepressants (0f potential use in DFSA) demonstrates exceptional separation performance with sensitive mass spectrometric detection.
In-line preconcentration and analysis of drugs in toxicological samples
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Using fluorescent derivatization and capillary and microfluidic detection techniques we can detect picogram quantities of drugs of abuse in toxicological samples. Our current projects seek to develop methods for in-line derivatization of compounds such as opiates and phenethyl amines followed by liquid based detection.
Al Najjar, A;Butcher, J; McCord, B. Determination of multiple drugs of abuse in human urine by capillary electrophoresis with fluorescence detection, Electrophoresis, 2004, 25 (10-11), 1592-1600.
Bishop, Sandra C.; Lerch, Margaret; McCord, Bruce R. “Detection of nitrated benzodiazepines by indirect laser induced fluorescence detection on a microfluidic device,” J. Chromatogr. A 2007, 1154(1-2), 481-484.
Blas, Maximilien; McCord, B. “Determination of trace levels of benzodiazepines in urine using capillary electrochromatography – time of flight mass spectrometry,” Electrophoresis 2008 29(10) 2182-2192
.Alnajjar, A. ,Idris A. M., Multzenberg, M. and McCord, B. “Development of a capillary electrophoresis method for the screening of human urine for multiple drugs of abuse J. Chromatogr. A, 2007, 856, 62-67
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